How Will You Sleep Tonight? It’s in Your Genes

By May 16, 2014 No Comments

Are you one of those people who rises before dawn and never needs an alarm clock? Or would you happily sleep until midmorning if you could? Do you feel like you are just hitting your stride by late afternoon, or do you get the day’s main tasks accomplished by lunch?

Most of us have some degree of preference for late nights or early mornings. Where an individual falls on this spectrum largely determines his or her chronotype—an individual disposition toward the timing of daily periods of activity and rest. Some of us are clearly “larks”—early risers—while others are distinctly night owls. The rest of us fall somewhere between the two.

We’re now learning that these night owl and early riser tendencies are driven to some significant degree by biological and genetic forces. Different chronotypes are associated with genetic variations, as well as differences in lifestyle and mood disposition, cognitive function, and risks for health problems including sleep disorders and depression.

For the study, researchers observed 59 men and women—16 early risers; 20 intermediate sleepers; and 23 night owls. They found that, compared to early risers and intermediates, night owls showed reduced integrity of white matter—the fatty tissue that facilitates communication among nerve cells—in several areas of the brain. Diminished integrity of white matter in the brain has been linked to depression and disruptions of normal cognitive function.

Are Night Owls at Risk?

The cause of this difference in white-matter quality between night owls and other sleepers is not clear. Researchers speculate that the diminished integrity of white matter may be a result of the chronic “social jet lag” that characterizes the effects many night owls’ sleep-wake routines—people who are disposed toward staying up late and sleeping late often find themselves at constant odds with work and school schedules that require early-morning starts. This can leave night owls chronically sleep deprived, experiencing many of the same symptoms of travel-induced jet lag, such as fatigue and daytime sleeplessness, difficulty focusing, and physical pain and discomfort.

Other research indicates that people who stay up late are at higher risk for depression, and are more prone to significant tobacco and alcohol use. They are also inclined to eat more, and to have less healthful diets than early risers or people with intermediate sleep patterns.

But it’s not all bad news for night owls. Some studies have shown that people who stay up late are more productive than early risers, and have more stamina throughout the length of the day. Other research has shown that night owls display greater reasoning and analytical abilities than earlier-to-bed peers. And, on average, research shows, they achieve greater financial and professional success than those with earlier bedtimes and wake times.

Sleeping in Your Genes

This latest study is the first to offer physical evidence of neurological differences among people with different sleep tendencies. But other research has also shown that the inclinations toward staying up late or rising early are deeply rooted in biological and genetic differences:

  • Scientists have discovered an “alarm clock” gene that activates the body’s biological clock in the morning from its period of overnight rest. Identifying this gene and its function may tell us important new information about the influence of chronotype and circadian function on sleep and health.
  • Research has also revealed differences in brain metabolic function among night owls compared to early risers and middle-of-the-road sleepers. These were discovered in regions of the brain involved in mood, and may be one reason night owls are at higher risk for depression related to insomnia.
  • Scientists identified a gene variant that exerts a strong influence over the circadian clock, and the inclination to stay up late or rise early. This variation—which affects nearly the entire population—can shift the timing of an individual’s 24-hour sleep-wake cycle by as much as 60 minutes.

If our preferences for sleep and wake times are strongly influenced by genetics and biology, what are we to do when our inclinations don’t match up with the demands and responsibilities of our lives? Genetic forces appear to play an important role in our preferences, but we’re still working to understand just how, and how much. And we’re far from powerless: The choices we make about our sleep environments and sleep habits can make a significant difference. A recent study showed that limiting nighttime exposure to artificial light, and increasing exposure to daytime sunlight, can shift sleep-wake cycles earlier—even for night owls. Improved habits—being careful about alcohol consumption close to bedtime; sticking to regular sleep and wake times; making sure your bedroom is dark and free of electronic gadgets—can help reinforce your sleep schedule, even if it doesn’t align perfectly with your natural tendencies.

More broadly, I hope we’ll see society begin to recognize the power of these biological sleep patterns, and the need for flexibility to enable people to construct work and school schedules that align better with their dispositions toward sleep. This is a smart strategy that would be good for public health and productivity.

This article was written by Michael J. Breus, PhD
The Sleep Doctor™
www.thesleepdoctor.com  and originally appeared here: http://www.psychologytoday.com/blog/sleep-newzzz/201311/how-will-you-sleep-tonight-its-in-your-genes



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